All about Dindolylmethane


Diindolylmethane (DIM) is a stable indole found in cruciferous vegetables which promotes a beneficial estrogen metabolism in both women and men.

Pure Diindolylmethane is insoluble and poorly absorbed by the human body.

*All published clinical studies have ONLY used the patented microencapsulated formulation of DIM.

The following definition of diindolylmethane was taken from
the National Cancer Institute:

A phytonutrient and plant indole found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale, with potential antiandrogenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. Check for active clinical trials using this agent. (NCI Thesaurus)

Abbreviation: DIM
Chemical structure name: 3,3'-diindoylmethane



Vegetable compound DIM may offer radiation therapy protection: Animal data

A compound derived from cruciferous vegetables could help to protect healthy tissue against damage during radiation therapy cancer treatment, according to new research in mice and rats.

Click here for the PDF of this studies Methods and Materials

New Study: Women with a BRCA1 mutation who have high risk for breast cancer receive significant benefit from oral microencapsulated DIM supplement:

BRCA1 mRNA levels following a 4-6 week intervention with oral 3,30 -diindolylmethane

New University of Arizona Clinical Trial:

Current Study: Effects of Micro-Encapsulated DIM with Tamoxifen in Breast Cancer

Active Clinical Trials:

Published Articles on Diindolylmethane (DIM):

DIM vs. I3C (Review)

DIM and I3C: The Real Facts on Safety

The Cruciferous Choice: DIM or I3C?

Safer Estrogen with Phytonutrition


Published Abstracts on Diindolylmethane and I3C:


Scientific Experts on Diindolylmethane and I3C:

H. Leon Bradlow, Ph.D.

Karen Auborn, Ph.D.

Carrie L. Daenell, N.D.



by Michael A. Zeligs, MD and A. Scott Connelly, MD
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